Survival in autoimmune hemolytic anemia remains poor, results from a nationwide cohort with 37 years of follow-up.

ABSTRACT:

Introduction

Autoimmune hemolytic anemia (AIHA) is considered a chronic disease, with an overall good prognosis. However, recent reports indicate pre-mature mortality. Causes of death have not been evaluated previously.

Methods

In a nationwide setting, we identified all patients with warm type AIHA or cold agglutinin disease (CAD), and age-sex-matched comparators from Denmark, 1980-2016. We estimated overall survival and cause-specific mortality from anemia, infection, cardiovascular causes, hematological or solid cancer, bleeding, or other causes, using cumulative incidence proportions.

Results

We identified 1460 patients with primary AIHA, 1078 with secondary AIHA, 112 with CAD, and 130 801 comparators. One-year survival and median survival were, 82.7% and 9.8 years

SUBMITTER: Hansen DL 

PROVIDER: S-EPMC9314695 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature