The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine.

ABSTRACT:

Background and purpose

Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), is a partial agonist at the μ opioid receptor. CYP3A-dependent oxidation of mitragynine yields the metabolite 7-OH mitragynine, a more efficacious μ receptor agonist. While both mitragynine and 7-OH mitragynine can induce anti-nociception in mice, recent evidence suggests that 7-OH mitragynine formed as a metabolite is sufficient to explain the anti-nociceptive effects of mitragynine. However, the ability of 7-OH mitragynine to induce μ receptor-dependent respiratory depression has not yet been studied.

Experimental approach

Respiration was measured in awake, freely moving, male CD-1 mice, using whole body plethysmography. Anti-nociception was measured using the hot plate assay. Morphine,

SUBMITTER: Hill R 

PROVIDER: S-EPMC9314834 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature