Review article: emerging insights into the immunopathology, clinical and therapeutic aspects of hepatitis delta virus.

ABSTRACT:

Background

Hepatitis delta virus (HDV), which causes the most severe form of viral hepatitis, is an obligated hepatitis B (HBV) satellite virus that can either infect naïve subjects simultaneously with HBV (co-infection), or chronically infect HBV carriers (super-infection). An estimated 12 million people are infected by HDV worldwide.

Aims

To summarise the most relevant aspects of the molecular biology of HDV, and to discuss the latest understanding of the induced pathology, interactions with the immune system, as well as both approved and investigational treatment options.

Methods

References for this review were identified through searches of PubMed with the terms "HDV" "viral hepatitis" "co-infection" and "super-infection," published between 1980 and October 2021 R

SUBMITTER: Usai C 

PROVIDER: S-EPMC9314912 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature