Chromosome size affects sequence divergence between species through the interplay of recombination and selection.

ABSTRACT: The structure of the genome shapes the distribution of genetic diversity and sequence divergence. To investigate how the relationship between chromosome size and recombination rate affects sequence divergence between species, we combined empirical analyses and evolutionary simulations. We estimated pairwise sequence divergence among 15 species from three different mammalian clades-Peromyscus rodents, Mus mice, and great apes-from chromosome-level genome assemblies. We found a strong significant negative correlation between chromosome size and sequence divergence in all species comparisons within the Peromyscus and great apes clades but not the Mus clade, suggesting that the dramatic chromosomal rearrangements among Mus species may have masked the ancestral genomic landscape of divergence i

SUBMITTER: Tigano A 

PROVIDER: S-EPMC9314927 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature