Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials.

ABSTRACT:

Aims

The melanocortin 4 receptor (MC4R) plays a central role in appetite regulation, and agonistic activity at this receptor promotes satiety. Results from two randomized controlled clinical trials examine the effects of bremelanotide's agonism at MC4R on caloric intake and body weight.

Methods

Premenopausal women with a body mass index >30 kg/m² were studied in two phase 1, single-centre, randomized, double-blind, placebo-controlled trials. Study A matched subjects 1:1 to receive subcutaneous placebo or bremelanotide three times daily for days 1-15. Study B was a crossover trial with six distinct treatment sequences consisting of three 4-day treatment periods, investigating once-a-day and twice-a-day exposure to bremelanotide versus placebo. Subjects received one

SUBMITTER: Spana C 

PROVIDER: S-EPMC9314948 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature