Genetic evidence for the most common risk factors for chronic axonal polyneuropathy in the general population.

ABSTRACT:

Background and purpose

Chronic axonal polyneuropathy is a common disease, but the etiology remains only partially understood. Previous etiologic studies have identified clinical risk factors, but genetic evidence supporting causality between these factors and polyneuropathy are largely lacking. In this study, we investigate whether there is a genetic association of clinically established important risk factors (diabetes, body mass index [BMI], vitamin B12 levels, and alcohol intake) with chronic axonal polyneuropathy.

Methods

This study was performed within the population-based Rotterdam Study and included 1565 participants (median age = 73.6 years, interquartile range = 64.6-78.8, 53.5% female), of whom 215 participants (13.7%) had polyneuropathy. Polygenic scores (PGSs) fo

SUBMITTER: Taams NE 

PROVIDER: S-EPMC9314974 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature