Midsagittal corpus callosal thickness and cognitive impairment in Parkinson's disease.

ABSTRACT: People diagnosed with Parkinson's disease (PD) can experience significant neuropsychiatric symptoms, including cognitive impairment and dementia, the neuroanatomical substrates of which are not fully characterised. Symptoms associated with cognitive impairment and dementia in PD may relate to direct structural changes to the corpus callosum via primary white matter pathology or as a secondary outcome due to the degeneration of cortical regions. Using magnetic resonance imaging, the corpus callosum can be investigated at the midsagittal plane, where it converges to a contiguous mass and is not intertwined with other tracts. The objective of this project was thus twofold: First, we investigated possible changes in the thickness of the midsagittal callosum and cortex in patients with PD with

SUBMITTER: Owens-Walton C 

PROVIDER: S-EPMC9314988 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature