The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation.

ABSTRACT: The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi-protein complex responsible for the activation of caspase-1 and the subsequent cleavage and activation of the potent proinflammatory cytokines IL-1β and IL-18, and pyroptotic cell death. NLRP3 is implicated as a driver of inflammation in a range of disorders including neurodegenerative diseases, type 2 diabetes, and atherosclerosis. A commonly reported mechanism contributing to NLRP3 inflammasome activation is potassium ion (K⁺ ) efflux across the plasma membrane. Identification of K⁺ channels involved in NLRP3 activation remains incomplete. Here, we investigated the role of the K⁺ channel THIK-1 in NLRP3 activation. Both pharmacological inhibitors and cells from THIK-1 knockout (KO)

SUBMITTER: Drinkall S 

PROVIDER: S-EPMC9314991 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature