Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise.

ABSTRACT: Muscle fibre denervation and declining numbers of muscle stem (satellite) cells are defining characteristics of ageing skeletal muscle. The aim of this study was to investigate the potential for lifelong recreational exercise to offset muscle fibre denervation and compromised satellite cell content and function, both at rest and under challenged conditions. Sixteen elderly lifelong recreational exercisers (LLEX) were studied alongside groups of age-matched sedentary (SED) and young subjects. Lean body mass and maximal voluntary contraction were assessed, and a strength training bout was performed. From muscle biopsies, tissue and primary myogenic cell cultures were analysed by immunofluorescence and RT-qPCR to assess myofibre denervation and satellite cell quantity and function. LLEX demon

SUBMITTER: Soendenbroe C 

PROVIDER: S-EPMC9315046 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature