Identification of Immune Microenvironment Changes and the Expression of Immune-Related Genes in Liver Cirrhosis.

ABSTRACT: Liver inflammation and the immune response have been recognized as critical contributors to cirrhosis pathogenesis. Immunity-related genes (IRGs) play an essential role in immune cell infiltration and immune reactions; however, the changes in the immune microenvironment and the expression of IRGs involved in cirrhosis remain unclear. CD45+ liver cell single-cell RNA (scRNA) sequencing data (GSE136103) from patients with cirrhosis were analyzed. The clusters were identified as known cell types through marker genes according to previous studies. GO and KEGG analyses among differentially expressed genes (DEGs) were performed. DEGs were screened to identify IRGs based on the ImmPort database. The protein-protein interaction (PPI) network of IRGs was generated using the STRING database. IRGs ac

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9315064 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature