Identification of SARS-CoV-2 inhibitors through phylogenetics and drug repurposing.

ABSTRACT: The novel coronavirus that has affected the whole world is declared a pandemic by the World Health Organization. Since the emergence of this virus, researchers worldwide have searched for potential antivirals against it. Being an RNA virus, it shows a high rate of mutability and variability in its genome. In the present study, all the reported SARS-CoV-2 genomes isolated from diverse regions of the world available in the GISAID database have been considered for phylogenetic analysis. The strain identified at the root is subjected to phylogenetic analysis with genomes of other known human viruses obtained from NCBI for identifying the nearest viral neighbor. Furthermore, the phylogenetic relationship between various human viruses was used to repurpose the known antiviral drugs towards coron

SUBMITTER: Mishra A 

PROVIDER: S-EPMC9315090 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature