Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media.

ABSTRACT: Intracellular nucleotide binding and oligomerization domain (NOD) and Toll-like (TLR) receptors have emerged as pivotal sensors of infection. Both Nod1 and Nod2 contain a caspase activation and recruitment domain (CARD) that interacts with the adaptor protein RIP2 (receptor-interaction protein-2). This leads to ubiquitination of RIP2 and in turn to the activation of NFκB and MAPK transcription factors, to command the host defensive response against pathogenic infections. RIP2 is also activated by TLRs 2 and 4, although the mechanism of this activation is less. The role of RIP2 in otitis media (OM) pathogenesis has yet to be examined. Herein, we used in vivo animal models including C57BL/6 wild-type (WT) and RIP2^-/- knockout mice inoculated in the middle ear (ME) with non-

SUBMITTER: Kurabi A 

PROVIDER: S-EPMC9315102 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature