Insights from shotgun metagenomics into bacterial species and metabolic pathways associated with NAFLD in obese youth.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease and is often the precursor for more serious liver conditions such as nonalcoholic steatohepatitis and cirrhosis. Although the gut microbiome has been implicated in the development of NAFLD, the strong association of obesity with NAFLD and its effect on microbiome structure has made interpreting study outcomes difficult. In the present study, we examined the taxonomic and functional differences between the microbiomes of youth with obesity and with and without NAFLD. Shotgun metagenome sequencing was performed to profile the microbiomes of 36 subjects, half of whom were diagnosed with NAFLD using abdominal magnetic resonance imaging. Beta diversity analysis showed community-wide differences between the groups

SUBMITTER: Testerman T 

PROVIDER: S-EPMC9315112 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature