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Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles as Potential Drug Carriers.

ABSTRACT: A series of thermo- and light-responsive copolymers of poly (N-isopropylacrylamide) (PNIPAM) and 6-[4-(4-methoxy phenyl azo)-phenoxyl-hexyl methacrylate) (AzoMA) (PNIPAM-b-PAzoMA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) radical polymerization. The resulting copolymers had a narrow molecular weight distribution range of 1.06-1.24, in which M n changed regularly with the monomer concentration. Subsequently, the diblock copolymers were successfully modified on the surface of iron oxide nanoparticles through the interaction between the chemical bonds to prepare Fe3O4@(PNIPAM-b-PAzoMA) nanoparticles. The size of fabricated nanoparticles with excellent thermo-sensitivity and photo-sensitivity was controlled at about 40-50 nm. Cell viability assays suggested that the nanoparticles showed no significant cytotoxicity and potential drug delivery in the tumor microenvironment.

SUBMITTER: Cui G 

PROVIDER: S-EPMC9315361 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles as Potential Drug Carriers.

Cui Guihua G   Wang Hao H   Long Shengsen S   Zhang Tianshuo T   Guo Xiaoyu X   Chen Shuiying S   Kakuchi Toyoji T   Duan Qian Q   Zhao Donghai D  

Frontiers in bioengineering and biotechnology 20220712

A series of thermo- and light-responsive copolymers of poly (<i>N</i>-isopropylacrylamide) (PNIPAM) and 6-[4-(4-methoxy phenyl azo)-phenoxyl-hexyl methacrylate) (AzoMA) (PNIPAM-b-PAzoMA) were synthesized <i>via</i> reversible addition-fragmentation chain transfer (RAFT) radical polymerization. The resulting copolymers had a narrow molecular weight distribution range of 1.06-1.24, in which <i>M</i> <sub>n</sub> changed regularly with the monomer concentration. Subsequently, the diblock copolymers  ...[more]

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