Ontology highlight
ABSTRACT:
SUBMITTER: Wilcox BK
PROVIDER: S-EPMC9315625 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Wilcox Brooke K BK Henley Marissa R MR Navaneethabalakrishnan Shobana S Martinez Karina A KA Pournouri Anil A Goodlett Bethany L BL Lopez Alexandra H AH Allbee Miranda L ML Pickup Emma J EJ Bayless Kayla J KJ Chakraborty Sanjukta S Mitchell Brett M BM
Cells 20220707 14
(1) Background: Renal immune cells and lymphatic vessel (LV) density have been reported previously to be increased in multiple mouse models of hypertension (HTN). However, whether interstitial levels of HTN stimuli such as angiotensin II, salt, or asymmetric dimethylarginine have a direct or indirect effect on lymphangiogenesis is unknown. We hypothesized that these 3 HTN stimuli directly increase lymphatic endothelial cell (LEC) proliferation, LEC 3-D matrix invasion and vessel formation, and s ...[more]