Exploratory Analysis of Serial ¹⁸F-fluciclovine PET-CT and Multiparametric MRI during Chemoradiation for Glioblastoma.

ABSTRACT: Anti-1-amino-3-¹⁸fluorine-fluorocyclobutane-1-carboxylic acid (¹⁸F-fluciclovine) positron emission tomography (PET) shows preferential glioma uptake but there is little data on how uptake correlates with post-contrast T1-weighted (Gd-T1) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) activity during adjuvant treatment. This pilot study aimed to compare ¹⁸F-fluciclovine PET, DCE-MRI and Gd-T1 in patients undergoing chemoradiotherapy for glioblastoma (GBM), and in a parallel pre-clinical GBM model, to investigate correlation between ¹⁸F-fluciclovine uptake, MRI findings, and tumour biology. ¹⁸F-fluciclovine-PET-computed tomography (PET-CT) and MRI including DCE-MRI were acquired before, during and after adjuvant chemo

SUBMITTER: Fatania K 

PROVIDER: S-EPMC9315674 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature