Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target.

ABSTRACT: Pancreatic cancer is known to have the lowest survival outcomes among all major cancers, and unfortunately, this has only been marginally improved over last four decades. The innate characteristics of pancreatic cancer include an aggressive and fast-growing nature from powerful driver mutations, a highly defensive tumor microenvironment and the upregulation of advantageous survival pathways such as autophagy. Autophagy involves targeted degradation of proteins and organelles to provide a secondary source of cellular supplies to maintain cell growth. Elevated autophagic activity in pancreatic cancer is recognized as a major survival pathway as it provides a plethora of support for tumors by supplying vital resources, maintaining tumour survival under the stressful microenvironment and promo

SUBMITTER: Gillson J 

PROVIDER: S-EPMC9315706 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature