Changes of Immune Cell Fractions in Patients Treated with Immune Checkpoint Inhibitors.

ABSTRACT:

Background

With the development of immunology, immune checkpoint inhibitors (ICIs) have been widely used in various cancer treatments. Although some patients can benefit from ICIs, other patients have no response to ICIs or suffer from hyperprogression. There has been no biomarker for predicting the efficacy of ICIs. Thus, the objective of this study was to find biomarkers for predicting the efficacy of ICIs using peripheral blood.

Methods

Adults patients planned to be treated with ICIs were enrolled in this study. Blood sampling was carried out before and after administration of ICIs. Changes of immune cell fraction were analyzed for each patient.

Results

Among 182 patients enrolled, immune cell analysis was performed for 90 patients. The objective response rate was

SUBMITTER: Kim HR 

PROVIDER: S-EPMC9315861 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature