Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review.

ABSTRACT:

Introduction

5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to penetrate the blood-brain barrier accumulating in malignant glioma cells with high selectivity, sensitivity and positive predictive value. However, those have yet to be explored aiding diagnosis for tumours of the central nervous system (CNS) other than high-grade gliomas (HGG). No up-to-date systematic review exists reporting the major surgical outcomes and diagnostic accuracy. We sought to conduct a systematic review of the literature summarising surgical outcomes, evaluate the quality of diagnostic accuracy reported in the literature and qualitatively assess the

SUBMITTER: Solomou G 

PROVIDER: S-EPMC9315896 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature