Ontology highlight
ABSTRACT:
SUBMITTER: Kaufman M
PROVIDER: S-EPMC9315922 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Kaufman Matthew M Yan Xiao-Jie XJ Li Wentian W Ghia Emanuela M EM Langerak Anton W AW Rassenti Laura Z LZ Belessi Chrysoula C Kay Neil E NE Davi Frederic F Byrd John C JC Pospisilova Sarka S Brown Jennifer R JR Catherwood Mark M Davis Zadie Z Oscier David D Montillo Marco M Trentin Livio L Rosenquist Richard R Ghia Paolo P Barrientos Jacqueline C JC Kolitz Jonathan E JE Allen Steven L SL Rai Kanti R KR Stamatopoulos Kostas K Kipps Thomas J TJ Neuberg Donna D Chiorazzi Nicholas N
Frontiers in oncology 20220712
Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that are more autoreactive and more effectively transduce signals to leukemic B cells, B-cell receptor (BCR) signaling is likely at the heart of the worse outcomes of CLL cases without/few IGHV mutations. A corollary of this conclusion is that M-CLL follow less aggressive clinical courses because somatic IGHV mutations have altered B ...[more]