Use of Publication Dynamics to Distinguish Cancer Genes and Bystander Genes.

ABSTRACT: de Magalhães has shown recently that most human genes have several papers in PubMed mentioning cancer, leading the author to suggest that every gene is associated with cancer, a conclusion that contradicts the widely held view that cancer is driven by a limited number of cancer genes, whereas the majority of genes are just bystanders in carcinogenesis. We have analyzed PubMed to decide whether publication metrics supports the distinction of bystander genes and cancer genes. The dynamics of publications on known cancer genes followed a similar pattern: seminal discoveries triggered a burst of cancer-related publications that validated and expanded the discovery, resulting in a rise both in the number and proportion of cancer-related publications on that gene. The dynamics of publications on

SUBMITTER: Banyai L 

PROVIDER: S-EPMC9315931 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature