Photothermal Regulated Nanozyme of CuFeS₂ Nanoparticles for Efficiently Promoting Wound Healing Infected by Multidrug Resistant Bacteria.

ABSTRACT: Peroxidase-mediated chemokinetic therapy (CDT) can effectively resist bacteria; however, factors such as the high dosage of drugs seriously limit the antibacterial effect. Herein, CuFeS₂ nanoparticles (NPs) nanozyme antibacterial system with the photothermal effect and peroxidase-like catalytic activity are proposed as a combined antibacterial agent with biosafety, high-efficiency, and broad-spectrum antibacterial ability. In addition, the as-obtained CuFeS₂ NPs with a low doses of Cu⁺ and Fe³⁺ can change the permeability of bacterial cell membranes and break the antioxidant balance by consuming intracellular glutathione (GSH), which results in more conducive ROS production. Meanwhile, the photothermal heating can regulate the CuFeS₂ N

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9315979 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature