Ciprofloxacin-Loaded Titanium Nanotubes Coated with Chitosan: A Promising Formulation with Sustained Release and Enhanced Antibacterial Properties.

ABSTRACT: Due to their high entrapment efficiency, anodized titanium nanotubes (TiO₂-NTs) are considered effective reservoirs for loading/releasing strong antibiotics whose systemic administration is associated with diverse and severe side-effects. In this study, TiO₂-NTs were synthesized by anodic oxidation of titanium foils, and the effects of electrolyte percentage and viscosity on their dimensions were evaluated. It was found that as the water content increased from 15 to 30%, the wall thickness, length, and inner diameter of the NTs increase from 5.9 to 15.8 nm, 1.56 to 3.21 µm, and 59 to 84 nm, respectively. Ciprofloxacin, a highly potent antibiotic, was loaded into TiO₂-NTs with a high encapsulation efficiency of 93%, followed by coating with different chitosa

SUBMITTER: Asadi S 

PROVIDER: S-EPMC9316085 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature