Can Modern Molecular Modeling Methods Help Find the Area of Potential Vulnerability of Flaviviruses?

ABSTRACT: Flaviviruses are single-stranded RNA viruses that have emerged in recent decades and infect up to 400 million people annually, causing a variety of potentially severe pathophysiological processes including hepatitis, encephalitis, hemorrhagic fever, tissues and capillaries damage. The Flaviviridae family is represented by four genera comprising 89 known virus species. There are no effective therapies available against many pathogenic flaviviruses. One of the promising strategies for flavivirus infections prevention and therapy is the use of neutralizing antibodies (NAb) that can disable the virus particles from infecting the host cells. The envelope protein (E protein) of flaviviruses is a three-domain structure that mediates the fusion of viral and host membranes delivering the inf

SUBMITTER: Shanshin DV 

PROVIDER: S-EPMC9316223 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature