CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.

ABSTRACT:

Background

Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. However, it's role in glioma, which is ranked as one of the common primary malignant tumor in the central nervous system and is associated with high morbidity and mortality, is unclear.

Methods

In this study, we explored CDC6 gene expression level in pan-cancer. Furthermore, we focused on the relationships between CDC6 expression, its prognostic value, potential biological functions, and immune infiltrates in glioma patients. We also performed vitro experiments to assess the effect of CDC6 expression on proliferative, apoptotic, migrant and invasive abilities of glioma cells.

Results

As a result, CDC6 expression was upregulated in mult

SUBMITTER: Wang F 

PROVIDER: S-EPMC9316328 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature