Integrated structure-based protein interface prediction.

ABSTRACT:

Background

Identifying protein interfaces can inform how proteins interact with their binding partners, uncover the regulatory mechanisms that control biological functions and guide the development of novel therapeutic agents. A variety of computational approaches have been developed for predicting a protein's interfacial residues from its known sequence and structure. Methods using the known three-dimensional structures of proteins can be template-based or template-free. Template-based methods have limited success in predicting interfaces when homologues with known complex structures are not available to use as templates. The prediction performance of template-free methods that only rely only upon proteins' intrinsic properties is limited by the amount of biologically relevant fea

SUBMITTER: Walder M 

PROVIDER: S-EPMC9316365 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature