Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors.

ABSTRACT: Tumors are still one of the main causes of death; therefore, the search for new therapeutic agents that will enable the implementation of effective treatment is a significant challenge for modern pharmacy. One of the important factors contributing to the development of neoplastic diseases is the overexpression of enzymes responsible for the regulation of cell division processes such as cyclin-dependent kinases. Numerous studies and examples of already-developed drugs confirm that isatin is a convenient basis for the development of new groups of inhibitors for this class of enzyme. Therefore, in this work, a new group of potential inhibitors of the CDK2 enzyme, utilizing isatin derivatives and substituted benzoylhydrazines, has been designed based on the application of computational chemist

SUBMITTER: Czelen P 

PROVIDER: S-EPMC9316372 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature