Molecular landscapes of human hippocampal immature neurons across lifespan.

ABSTRACT: Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents^1,2 and are dysregulated in multiple human neurological disorders^3-5. Little is known about the molecular characteristics of adult human hippocampal imGCs, and even their existence is under debate^1,6-8. Here we performed single-nucleus RNA sequencing aided by a validated machine learning-based analytic approach to identify imGCs and quantify their abundance in the human hippocampus at different stages across the lifespan. We identified common molecular hallmarks of human imGCs across the lifespan and observed age-dependent transcriptional dynamics in human imGCs that suggest changes in cellular functionality, niche

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9316413 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature