Genetic and epigenetic coordination of cortical interneuron development.

ABSTRACT: One of the hallmarks of the cerebral cortex is the extreme diversity of interneurons^1-3. The two largest subtypes of cortical interneurons, parvalbumin- and somatostatin-positive cells, are morphologically and functionally distinct in adulthood but arise from common lineages within the medial ganglionic eminence^4-11. This makes them an attractive model for studying the generation of cell diversity. Here we examine how developmental changes in transcription and chromatin structure enable these cells to acquire distinct identities in the mouse cortex. Generic interneuron features are first detected upon cell cycle exit through the opening of chromatin at distal elements. By constructing cell-type-specific gene regulatory networks, we observed that parvalbumin- and somat

SUBMITTER: Allaway KC 

PROVIDER: S-EPMC9316417 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature