Accurate Screening for Early-Stage Breast Cancer by Detection and Profiling of Circulating Tumor Cells.

ABSTRACT:

Background

The early detection of breast cancer (BrC) is associated with improved survival. We describe a blood-based breast cancer detection test based on functional enrichment of breast-adenocarcinoma-associated circulating tumor cells (BrAD-CTCs) and their identification via multiplexed fluorescence immunocytochemistry (ICC) profiling for GCDFP15, GATA3, EpCAM, PanCK, and CD45 status.

Methods

The ability of the test to differentiate BrC cases (N = 548) from healthy women (N = 9632) was evaluated in a case-control clinical study. The ability of the test to differentiate BrC cases from those with benign breast conditions was evaluated in a prospective clinical study of women (N = 141) suspected of BrC.

Results

The test accurately detects BrAD-CTC

SUBMITTER: Crook T 

PROVIDER: S-EPMC9316476 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature