Heritability Analyses Uncover Shared Genetic Effects of Lung Function and Change over Time.

ABSTRACT: Genetic influence on lung functions has been identified in previous studies; however, the relative longitudinal effects of genetic factors and their interactions with smoking on lung function remain unclear. Here, we identified the longitudinal effects of genetic variants on lung function by determining single nucleotide polymorphism (SNP) heritability and genetic correlations, and by analyzing interactions with smoking. Subject-specific means and annual change rates were calculated for eight spirometric measures obtained from 6622 Korean adults aged 40−69 years every two years for 14 years, and their heritabilities were estimated separately. Statistically significant (p < 0.05) heritability for the subject-specific means of all spirometric measures (8~32%) and change rates of forced expir

SUBMITTER: Li D 

PROVIDER: S-EPMC9316642 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature