Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study.

ABSTRACT:

Background

Anti-thyroid peroxidase antibody (TPOAb) positivity can contribute to inhibit thyroxine synthesis. Gut microbiota can interact with metabolic or immune diseases. However, dynamics of gut microbiota from the second (T2) to the third trimester (T3) in women with TPOAb-positive/negative subclinical hypothyroidism (TPOAb⁺/TPOAb^- SCH) have not been reported. Therefore, we aimed to evaluate whether gut microbiota can be potential therapeutic targets for managing TPOAb⁺ SCH.

Methods

In this single-center prospective cohort study, we observed gut microbiota dynamics by sequencing 16S rRNA from fecal samples collected in T2 (20-23^+ 6 weeks) and T3 (28-33^+ 6 weeks). TPOAb⁺/TPOAb^- SCH were stratifie

SUBMITTER: Wu M 

PROVIDER: S-EPMC9316685 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature