Insights on the Modulation of SIRT5 Activity: A Challenging Balance.
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ABSTRACT:
SUBMITTER: Mori M
PROVIDER: S-EPMC9316768 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Insights on the Modulation of SIRT5 Activity: A Challenging Balance.
Mori Matteo M Cazzaniga Giulia G Meneghetti Fiorella F Villa Stefania S Gelain Arianna A
Molecules (Basel, Switzerland) 20220712 14
SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging. Considering that the anomalous activity of SIRT5 is linked to many pathological conditions, we present herein an overview of the most interesting modulators, with the aim of contributing to further development in this field. ...[more]
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