Immune Correlates of Disseminated BCG Infection in IL12RB1-Deficient Mice.

ABSTRACT: Interleukin-12 receptor β1 (IL12RB1)-deficient individuals show increased susceptibilities to local or disseminated BCG infection and environmental mycobacteria infection. However, the low clinical penetrance of IL12RB1 deficiency and low recurrence rate of mycobacteria infection suggest that protective immunity still exists in this population. In this study, we investigated the mechanism of tuberculosis suppression using the IL12RB1-deficient mouse model. Our results manifested that Il12rb1^-/- mice had significantly increased CFU counts in spleens and lungs, especially when BCG (Danish strain) was inoculated subcutaneously. The innate TNF-a and IFN-γ responses decreased, while the IL-17 responses increased significantly in the lungs of Il12rb1^-/- mice.

SUBMITTER: Wang X 

PROVIDER: S-EPMC9316795 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature