Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond.

ABSTRACT: Respiratory infections with newly emerging zoonotic viruses such as SARS-CoV-2, the etiological agent of COVID-19, often lead to the perturbation of the human innate and adaptive immune responses causing severe disease with high mortality. The responsible mechanisms are commonly virus-specific and often include either over-activated or delayed local interferon responses, which facilitate efficient viral replication in the primary target organ, systemic viral spread, and rapid onset of organ-specific and harmful inflammatory responses. Despite the distinct replication strategies, human infections with SARS-CoV-2 and highly pathogenic avian influenza viruses demonstrate remarkable similarities and differences regarding the mechanisms of immune induction, disease dynamics, as well as the long

SUBMITTER: Faist A 

PROVIDER: S-EPMC9316821 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature