Ranolazine Counteracts Strength Impairment and Oxidative Stress in Aged Sarcopenic Mice.

ABSTRACT: Sarcopenia is defined as the loss of muscle mass associated with reduced strength leading to poor quality of life in elderly people. The decline of skeletal muscle performance is characterized by bioenergetic impairment and severe oxidative stress, and does not always strictly correlate with muscle mass loss. We chose to investigate the ability of the metabolic modulator Ranolazine to counteract skeletal muscle dysfunctions that occur with aging. For this purpose, we treated aged C57BL/6 mice with Ranolazine/vehicle for 14 days and collected the tibialis anterior and gastrocnemius muscles for histological and gene expression analyses, respectively. We found that Ranolazine treatment significantly increased the muscle strength of aged mice. At the histological level, we found

SUBMITTER: Torcinaro A 

PROVIDER: S-EPMC9316887 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature