Comprehensive Cytokine Profiling of Patients with COVID-19 Receiving Tocilizumab Therapy.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is characterized by immune activation in response to viral spread, in severe cases leading to the development of cytokine storm syndrome (CSS) and increased mortality. Despite its importance in prognosis, the pathophysiological mechanisms of CSS in COVID-19 remain to be defined. Towards this goal, we analyzed cytokine profiles and their interrelation in regard to anti-cytokine treatment with tocilizumab in 98 hospitalized patients with COVID-19. We performed a multiplex measurement of 41 circulating cytokines in the plasma of patients on admission and 3-5 days after, during the follow-up. Then we analyzed the patient groups separated in two ways: according to the clusterization of their blood cytokines and based on the administration of tocilizumab thera

SUBMITTER: Lebedeva A 

PROVIDER: S-EPMC9316906 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature