PEG-Free Polyion Complex Nanocarriers for Brain-Derived Neurotrophic Factor.

ABSTRACT: Many therapeutic formulations incorporate poly(ethylene glycol) (PEG) as a stealth component to minimize early clearance. However, PEG is immunogenic and susceptible to accelerated clearance after multiple administrations. Here, we present two novel reformulations of a polyion complex (PIC), originally composed of poly(ethylene glycol)₁₁₃-b-poly(glutamic acid)₅₀ (PEG-PLE) and brain-derived neurotrophic factor (BDNF), termed Nano-BDNF (Nano-BDNF PEG-PLE). We replace the PEG based block copolymer with two new polymers, poly(sarcosine)₁₂₇-b-poly(glutamic acid)₅₀ (PSR-PLE) and poly(methyl-2-oxazolines)₃₈-b-poly(oxazolepropanoic acid)₂₇-b-poly(methyl-2-oxazoline)₃₈ (PMeOx-PPaOx-PMeOx), which are driven to

SUBMITTER: Fay JM 

PROVIDER: S-EPMC9317007 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature