Real-World Evidence of the Effectiveness and Safety of Ustekinumab for the Treatment of Crohn's Disease: Systematic Review and Meta-Analysis of Observational Studies.

ABSTRACT: (1) Background: Evidence on the outcomes of ustekinumab treatment in real-world Crohn's disease (CD) patients is needed. Our aim was to evaluate the effectiveness and safety of ustekinumab in CD, reported by observational studies. (2) Methods: bibliographical searches were performed (PubMed, EMBASE).

Selection

observational studies assessing the effectiveness and safety of ustekinumab in CD.

Exclusion criteria

studies using ustekinumab as a prophylaxis for postoperative recurrence or perianal disease.

Data synthesis

effectiveness by intention-to-treat (random-effects model). Data were stratified by study design, population included, administered dose, and prior biologic exposure. (3) Results: A total of 63 studies (8529 patients) were included. Response was achieved in

SUBMITTER: Rubin de Celix C 

PROVIDER: S-EPMC9317084 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature