Molecular Alterations Caused by Alcohol Consumption in the UK Biobank: A Mendelian Randomisation Study.

ABSTRACT: Alcohol consumption is associated with the development of cardiovascular diseases, cancer, and liver disease. The biological mechanisms are still largely unclear. Here, we aimed to use an agnostic approach to identify phenotypes mediating the effect of alcohol on various diseases.

Methods

We performed an agnostic association analysis between alcohol consumption (red and white wine, beer/cider, fortified wine, and spirits) with over 7800 phenotypes from the UK biobank comprising 223,728 participants. We performed Mendelian randomisation analysis to infer causality. We additionally performed a Phenome-wide association analysis and a mediation analysis between alcohol consumption as exposure, phenotypes in a causal relationship with alcohol consumption as mediators, and various disease

SUBMITTER: O'Farrell F 

PROVIDER: S-EPMC9317105 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature