Network pharmacology-based analysis and experimental in vitro validation on the mechanism of Paeonia lactiflora Pall. in the treatment for type I allergy.

ABSTRACT:

Background

The incidence of allergic reaction is increasing year by year, but the specific mechanism is still unclear. Paeonia lactiflora Pall.(PLP) is a traditional Chinese medicine with various pharmacological effects such as anti-tumor, anti-inflammatory, and immune regulation. Previous studies have shown that PLP has potential anti-allergic activity. However, there is still no comprehensive analysis of the targeted effects and exact molecular mechanisms of the anti-allergic components of PLP. This study aimed to reveal the mechanism of PLP. in the treatment of type I allergy by combining network pharmacological methods and experimental verification.

Methods

First, we used the traditional Chinese medicine systems pharmacology (TCMSP) database and analysis platform to scre

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9317138 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature