Mild to moderate decrease in eGFR and cognitive decline in older adults.

ABSTRACT:

Background

Whether mild to moderately low estimated glomerular filtration rate (eGFR) is associated with cognitive decline in older adults is not clear. We evaluated changes in cognition in relation to baseline eGFR in older adults participating in the Alzheimer's Disease Neuroimaging Initiative (ADNI).

Methods

This is a longitudinal secondary analysis of an established observational cohort. We used data from the ADNI, an National Institutes of Health-funded, multicenter longitudinal observational study that includes participants with and without cognitive impairment who were administered a comprehensive battery of neuropsychological tests every 6 months. We related the Chronic Kidney Disease Epidemiology Collaboration eGFR with previously validated cognition composite score

SUBMITTER: Grasing M 

PROVIDER: S-EPMC9317170 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature