Influence of Addition of Antibiotics on Chemical and Surface Properties of Sol-Gel Coatings.

ABSTRACT: Infection is one of the most common causes that leads to joint prosthesis failure. In the present work, biodegradable sol-gel coatings were investigated as a promising controlled release of antibiotics for the local prevention of infection in joint prostheses. Accordingly, a sol-gel formulation was designed to be tested as a carrier for 8 different individually loaded antimicrobials. Sols were prepared from a mixture of MAPTMS and TMOS silanes, tris(tri-methylsilyl)phosphite, and the corresponding antimicrobial. In order to study the cross-linking and surface of the coatings, a battery of examinations (Fourier-transform infrared spectroscopy, solid-state ²⁹Si-NMR spectroscopy, thermogravimetric analysis, SEM, EDS, AFM, and water contact angle, thickness, and roughness measuremen

SUBMITTER: Toirac B 

PROVIDER: S-EPMC9317242 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature