Correlation of Body Mass Index and Proinflammatory Cytokine Levels with Hematopoietic Stem Cell Mobilization.

ABSTRACT: This study investigated the correlation of body mass index (BMI) and proinflammatory cytokine levels with hematopoietic stem cell (HSC) mobilization triggered by granulocyte colony-stimulating factor (G-CSF). Stem cell donors (n = 309) were recruited between August 2015 and January 2018 and grouped into four groups according to their BMI: underweight (BMI < 18.5 kg/m², n = 10), normal (18.5 kg/m² ≦ BMI < 25 kg/m², n = 156), overweight (25 kg/m² ≦ BMI < 30 kg/m², n = 102), and obese (BMI ≧ 30 kg/m², n = 41). The participants were then administered with five doses of G-CSF and categorized as good mobilizers (CD34 ≧ 180/μL, n = 15, 4.85%) and poor mobilizers (CD34 ≦ 25/μL, n

SUBMITTER: Wang TF 

PROVIDER: S-EPMC9317243 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature