Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H₂O₂-Induced Cytotoxicity in Tumour Cells.

ABSTRACT: Among known phenolic antioxidants, the overwhelming majority of compounds have lipophilic properties and the number of known water-soluble compounds is very small. The list of hydrophilic phenolic antioxidants can be expanded via the synthesis of a structurally related series of polyfunctional compounds for further research on their biological activity in vitro. New sulphur- and selenium-containing analogues of antioxidant potassium phenosan were synthesised. In vitro cytotoxicity and cytostaticity as well as antioxidant activity against H₂O₂-induced cytotoxicity to human cell lines (HepG2, Hep-2 and MCF-7) were investigated by high-content analysis. A selenium-containing analogue showed higher biological activity than did a sulphur-containing one. As compared to the

SUBMITTER: Klyushova LS 

PROVIDER: S-EPMC9317250 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature