Chalcones as Potential Ligands for the Treatment of Parkinson's Disease.

ABSTRACT: Along with the increase in life expectancy, a significant increase of people suffering from neurodegenerative diseases (ND) has been noticed. The second most common ND, after Alzheimer's disease, is Parkinson's disease (PD), which manifests itself with a number of motor and non-motor symptoms that hinder the patient's life. Current therapies can only alleviate those symptoms and slow down the progression of the disease, but not effectively cure it. So now, in addition to understanding the mechanism and causes of PD, it is also important to find a powerful way of treatment. It has been proved that in the etiology and course of PD, the essential roles are played by dopamine (DA) (an important neurotransmitter), enzymes regulating its level (e.g., COMT, MAO), and oxidative stress leading to n

SUBMITTER: Krolicka E 

PROVIDER: S-EPMC9317344 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature