MicrobiomeGWAS: A Tool for Identifying Host Genetic Variants Associated with Microbiome Composition.

ABSTRACT: The microbiome is the collection of all microbial genes and can be investigated by sequencing highly variable regions of 16S ribosomal RNA (rRNA) genes. Evidence suggests that environmental factors and host genetics may interact to impact human microbiome composition. Identifying host genetic variants associated with human microbiome composition not only provides clues for characterizing microbiome variation but also helps to elucidate biological mechanisms of genetic associations, prioritize genetic variants, and improve genetic risk prediction. Since a microbiota functions as a community, it is best characterized by β diversity; that is, a pairwise distance matrix. We develop a statistical framework and a computationally efficient software package, microbiomeGWAS, for identifying host ge

SUBMITTER: Hua X 

PROVIDER: S-EPMC9317577 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature