Nipah Virus Infection Generates Ordered Structures in Cellulo.

ABSTRACT: Nipah virus (NiV) is a zoonotic paramyxovirus with a fatality rate of up to 92% in humans. While several pathogenic mechanisms used by NiV to counteract host immune defense responses have been described, all of the processes that take place in cells during infection are not fully characterized. Here, we describe the formation of ordered intracellular structures during NiV infection. We observed that these structures are formed specifically during NiV infection, but not with other viruses from the same Mononegavirales order (namely Ebola virus) or from other orders such as Bunyavirales (Junín virus). We also determined the kinetics of the appearance of these structures and their cellular localization at the cellular periphery. Finally, we confirmed the presence of these NiV-sp

SUBMITTER: Vazquez CA 

PROVIDER: S-EPMC9317923 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature