Acne, Microbiome, and Probiotics: The Gut-Skin Axis.

ABSTRACT: The objective of this narrative review was to check the influence of the human microbiota in the pathogenesis of acne and how the treatment with probiotics as adjuvant or alternative therapy affects the evolution of acne vulgaris. Acne is a chronic inflammatory skin disease involving the pilosebaceous units. The pathogenesis of acne is complex and multifactorial involving genetic, metabolic, and hormonal factors in which both skin and gut microbiota are implicated. Numerous studies have shown the bidirectionality between the intestinal microbiota and skin homeostasis, a communication mainly established by modifying the immune system. Increased data on the mechanisms of action regarding the relevance of Cutibacterium acnes, as well as the importance of the gut-skin axis, are becoming

SUBMITTER: Sanchez-Pellicer P 

PROVIDER: S-EPMC9318165 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature