Circulating Metabolites in Relation to the Kidney Allograft Function in Posttransplant Patients.

ABSTRACT: End-stage kidney disease is preferably treated by kidney transplantation. The suboptimal function of the allograft often results in misbalances in kidney-controlled processes and requires long-term monitoring of allograft function and viability. As the kidneys are organs with a very high metabolomic rate, a metabolomics approach is suitable to describe systematic changes in post-transplant patients and has great potential for monitoring allograft function, which has not been described yet. In this study, we used blood plasma samples from 55 patients after primary kidney transplantation identically treated with immunosuppressants with follow-up 50 months in the mean after surgery and evaluated relative levels of basal plasma metabolites detectable by NMR spectroscopy. We were looking for th

SUBMITTER: Baranovicova E 

PROVIDER: S-EPMC9318187 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature